Tiny sugars in the brain disrupt emotional circuits, fueling depression

Depression is a serious disorder that disrupts daily life through lethargy, sleep disturbance, and social withdrawal, and also increases the risk of suicide. The number of depression patients has steadily increased over the years, affecting more than 280 million people worldwide as of 2025. Now, researchers have uncovered a new pathological mechanism that could provide clues for the diagnosis and treatment of depression.

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