How bacteria that cause inflammatory colitis outmaneuver our body's defenses

Bacteria use multiple defense mechanisms to survive in the host body. Shigella bacteria that cause colitis disable multiple host defense pathways using three specialized effector proteins, as reported by researchers from Japan. They found that these effectors suppress inflammation, block apoptosis, and prevent necroptosis in human cells, allowing the pathogen to replicate. This study offers new insights that could help develop vaccines and targeted therapies to manage inflammatory colitis.

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