Blood stem cell metabolism tracked through aging and cancer development

Researchers from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and ETH Zurich have created the first integrated map detailing the metabolic and molecular changes in human blood stem cells as they age, specialize, or turn cancerous. Their innovative research, made possible by highly sensitive low-input techniques, identifies the nutrient choline as a key player in preserving youthful stem cell traits. This work offers profound insights into stem cell health and disease, suggesting promising directions for nutritional and therapeutic interventions to maintain a healthy blood system.

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