A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder

Stress-related disorders stem from the interplay of genetic susceptibility and stress exposure, shaping gene and protein expression through epigenetic modifications across the lifespan. Studies on postmortem brains of post-traumatic stress disorder (PTSD) and major depression (MDD) patients, compared to neurotypical controls, have revealed genetic overlap, sex differences, and immune and interneuron signaling involvement, yet lack integrative analyses.

👉 Full Story