Scalable technique for single-cell sequencing enhances drug screening research

A study by scientists at the Herbert Irving Comprehensive Cancer Center (HICCC) introduces a more cost-effective, scalable single-cell sequencing technique for co-sequencing RNA and DNA. The tool, called DEFND-seq (DNA and Expression Following Nucleosome Depletion sequencing), uses an existing microfluidics platform that can process cells in parallel, allowing cancer researchers to better explore questions related to disease progression, tumor evolution, and drug resistance.

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