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Wednesday, April 30, 2025
Next-gen flu vaccines use proteolysis-targeting to boost safety and cross-strain immunity in animal models
Recently, Prof. Si Longlong's team from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences constructed a library of live-attenuated influenza A vaccines that utilize diverse E3 ubiquitin ligases to degrade viral proteins and achieve virus attenuation, and developed the next-generation proteolysis-targeting (PROTAR) strategy, PROTAR 2.0.
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