Challenges, innovations and future directions in dengue vaccine development

Dengue fever, caused by a flavivirus named DENV, is a major global health challenge, risking almost half of the world's population. Since the early 20th century, the scientific community has faced multiple challenges in developing effective dengue vaccines. This spanned a variety of techniques—from the use of ox bile to weaken DENV to the chemical processing of DENV-infected mosquitoes. However, the limitations of these techniques and the urgent need to save millions of people from the infection in its endemic regions led to the development of more sophisticated dengue vaccines.

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