Researchers uncover mechanisms of initiation and progression in basal cell carcinoma

An international team, co-led by Adriana Sánchez-Danés, principal investigator of the Cancer and Stem Cell Biology Lab at the Champalimaud Foundation, in Lisbon, has shown for the first time the important role of Survivin—a protein that has key roles in regulating cell division and inhibiting apoptosis (programmed cell death)—in the initiation and formation of a basal cell carcinoma, the most common human skin cancer. Their results have now been published in Cancer Discovery.

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